Integrins for mitosis

Using Integrins for Tumor Imaging

0173 For disease outbreak detection, the public-health community has historically relied on the watchful eyes of doctors and other health-care workers, who have reported individual cases or clusters of cases of particular diseases to healthcare and other authorities. The increased availability of electronic health-care data, however, raises the possibility of more automated and earlier outbreak...

Mitosis: Springtime for Chromatin

When a eukaryotic cell divides, tension builds at centromeres as spindle forces pull chromosomes toward opposite poles during metaphase. New data show that centromeric chromatin stretches in response to these forces, revealing a mechanical role for chromatin packaging in mitosis.

Neuroblastoma Integrins

Searching for gold beyond mitosis

The genetically tractable filamentous ascomycete fungus Aspergillus nidulans has been successfully exploited to gain major insight into the eukaryotic cell cycle. More recently, its amenability to in vivo multidimensional microscopy has fueled a potentially gilded second age of A. nidulans cell biology studies. This review specifically deals with studies on intracellular membrane traffic in A. ...

Integrins as receptor targets for neurological disorders.

This review focuses on the neurobiology of integrins, pathophysiological roles of integrins in neuroplasticity and nervous system disorders, and therapeutic implications of integrins as potential drug targets and possible delivery pathways. Neuroplasticity is a central phenomenon in many neurological conditions such as seizures, trauma, and traumatic brain injury. During the course of many brai...